Scientists Found New Way to Treat Acute Pancreatitis
Here is good news for the people with the pancreatitis. Now they may expect to get rid of long time preventions and insulin pills. The researchers have found a unique method about which they hope to find the permanent treatment of pancreatitis. Although the pancreatitis is being treated with different helping medicines and preventions but till this time there is no treatment which may eliminate this disease permanently. The fresh research is showing hope to find the constant treatment of acute pancreatitis with medicines. Let us see how did scientists get it?
The pancreatitis is the disease of pancreas. It makes the pancreas inflamed and cause the death if its cells. The pancreas produces some juices and enzymes which are sent to intestines to help digestions. These enzymes stay deactivated in the pancreas and only activate in the intestine. The pancreas cells have a natural storage of calcium. They don’t allow external calcium to enter as this may activate the enzymes within the body of pancreas. This inside activated enzymes start digesting pancreas cells and consequently killing them.
Alcohol, the major cause of Pancreatitis, causes disturbance. The mixture of alcohol and fatty acids produces an atmosphere which compels the calcium inside the pancreas cells to excrete out. The whole calcium is expelled out and the cells get empty of calcium. As a result these cells become attractive to external calcium and are opened to get the same. The external calcium enters the cells, activates the inactive enzymes and causes internal cells digestions. The pancreas cells start getting damaged and dying. The whole purpose of study was to know how to stop this external calcium to enter the pancreas cells and observe the outcomes.
The researchers tested some chemicals to see if some of those may block calcium entry. They found that an already existing chemical can do this. A substance marketed by an international drug manufacturer company was succeeded to stop the calcium to enter the pancreas cells. The further tests showed that the cells blocked for calcium entry were neither being digested nor getting pancreatitis. The scientists are hopefully thinking that medicinal treatment of pancreas will now be possible. When the medicines will simply block the external calcium entrance, the enzymes will not get activated within the boundary of pancreas. They will not be able to damage or digest the pancreas cells and cause pancreatitis.
The research was carried out at Cardiff University by a team of scientists headed by MRC Professor Ole Petersen. He is director of Cardiff University’s School of Biosciences. Dr Joe McNamara, Population and Systems Medicine Board Chair at the Medical Research Council provided £2.3M for the study. The grant was subjected under MRC – Medical Research Council Program. The results were issued in the journal of Proceedings of the National Academy of Sciences (PNAS) in USA.
According to Ole Petersen, in a previous research they have discovered that the external calcium entrance stimulates the enzymes to activate suddenly within the pancreas cells. This time they were experimenting to find something which may stop this activation. It was only possible when the external calcium may not enter these cells. So they needed something to stop this entrance. Now, when they have got it, it will become possible to treat acute pancreatitis with medicines. He hoped that some further experiments will bring new method to eradicate pancreatitis. He claimed that the medical science has no proper medicine-base treatment of this disease but now they have discovered it. Dr Joe McNamara expressed that although they need some further tests on animal and human cells but they have found the base. He was very glad with the outcomes of the study and declared it a milestone in the treatment of pancreatitis.
Pancreatitis is a complicating disease. It not only damages the pancreas but causes many other troubles. Pancreatitis may cause kidney failure, breathing problems, Pseudo-cyst, malnutrition and even pancreatic cancer. In some cases it may be life threatening case. The study has brought no doubt a new optimism in this regard. The pancreatitis will perhaps now be dealt with properly.